Modeling and Validation of the Human Liver and Kidney Models
ثبت نشده
چکیده
The objective of this study is to develop robust finite element models of the liver and kidney. The organs are modeled for the first time as hyper viscoelastic materials and with individual constituents of each (viz. the capsule and veins). To characterize the tissues, static and dynamic experiments were performed on individual parts of the porcine abdominal organs, such as capsule, vessels and parenchyma and hyper elastic, visco elastic and hyper viscoelastic materials in the form of Ogden, Mooney Rivlin and Maxwell materials were developed for each. These material models were further used to develop the finite element model of human organs. To validate these models in vitro dynamic tests on porcine kidneys were performed, whereas dynamic impact test data from the literature on human liver were used. Experiments were reproduced with the numerical approach in the LS Dyna explicit solver. The developed models are observed to reproduce the injuries of the organ to a great extent in terms of acceleration and peak force of the impactor as well as lacerations sustained by the organ during the experiments. The developed models are robust and can be integrated with the available human body finite element models to simulate accidents and to predict or simulate injuries.
منابع مشابه
Measurement of cadmium residues in muscle, liver and kidney of cattle slaughtered in Isfahan abattoir using grafite furnace atomic absorption spectrometry (GFAAS): a preliminary study
The aim of the present study was to determine the levels of cadmium in the muscle, liver and kidney of cattle from Isfahan and to compare the results with those reported by other countries and with the maximum acceptable levels for human consumption. Samples of muscle, liver and kidney from 60 animals aged 1–10- year-old were collected from the carcasses slaughtered at Isfahan abattoir. Samples...
متن کاملApplication of NCEPCFSR Climatic Database Information in the Absence of Observational Information of Dez Dam Watershed
Rainfall-Runoff simulation is one of the main subject of hydrology and environmental management. Therefore, researchers are constantly interested in finding new ways to solve this problem and modify existing models or modeling methods. However, the lack of statistics and information from the poor development of hydrological networks has always been a major problem in countries that facing finan...
متن کاملAnimal Models Of Liver Cirrhosis And Fibrosis
Animal modeling is a crucial necessity in clinical studies of liver diseases. Authenticity of the data which are produced using this tool under different conditions and accuracy of the analyses and assessments which would be based on such data sets is completely dependent on the adoption of a standardized methodology for analyzes and assessment of these data sets. Cirrhosis and Fibrosis are amo...
متن کاملAcute Toxicity of Onion Skin Quercetin and its Effect on Liver and Kidney of Mice
Quercetin is the most abundant flavonoid molecules, widely distributed in the plant kingdom and has a wide range of uses. The aim of the study was to determine the LD50 of onion skin quercetin (OSQ) and its effect on the liver and kidney of mice. The study consists of 2 phases. In phase 1, nine mice BALB/c were divided into three groups of three mice each. The mice in each group received OSQ at...
متن کاملComparison of Artificial Neural Networks and Cox Regression Models in Prediction of Kidney Transplant Survival
Cox regression model serves as a statistical method for analyzing the survival data, which requires some options such as hazard proportionality. In recent decades, artificial neural network model has been increasingly applied to predict survival data. This research was conducted to compare Cox regression and artificial neural network models in prediction of kidney transplant survival. The prese...
متن کاملInvestigating the Safety of Bee Pollen on Performance, Oxidative Stress and Histopathological Changes in the Liver, Kidney and Pancreas of Rats
Objective: The therapeutic effects of bee pollen have been proven in various studies, but toxicity studies in this field are limited. Therefore, in this study the possible toxicity effects of hydroalcoholic extract of flower pollen on liver, kidney and pancreatic tissues of male rats was investigated. Methods: Fourteen male rats were divided into two groups of seven: the first group received 8...
متن کامل